Cognitive · ~3 min read
P-21: What It Is, How It Works & What the Research Shows
Overview
Peptide fragment of CNTF designed to promote neurogenesis without CNTF's side effects. Studied for memory and neurodegeneration models.
How it works
Peptide fragment of CNTF designed to promote neurogenesis without CNTF's side effects. Studied for memory and neurodegeneration models.
Adamantane & the blood–brain barrier
Chemically attaching an adamantane group to a peptide can increase its lipid (fat) solubility. Researchers hypothesize that this modification may help certain compounds cross the tightly regulated blood–brain barrier. The effect depends on the specific modified molecule; greater lipid solubility alone does not establish brain delivery or clinical benefit. This does not apply automatically to the unmodified peptide and is not a reconstitution additive.
What the research shows
- Neurogenesis
- Memory support
- Neuroprotection
Typical protocol
Community-reported range (unverified): 1–5 mg/day SC/PO
Community-reported range (unverified); not a clinically verified schedule.
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Sources
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