01 / RESEARCH SUMMARY
CJC-1295 (no DAC) + IPA Research Summary
This blend combines two growth hormone secretagogues that work through different receptors. CJC-1295 without DAC (modified GRF 1-29) is a GHRH analog that signals the pituitary to release growth hormone, with a half-life of about 30 minutes. Ipamorelin activates the ghrelin receptor, triggering a growth hormone pulse with little effect on cortisol or prolactin. Studies of GHRH and ghrelin-pathway agonists given together show a synergistic, larger GH release than either alone, which is the rationale for pairing them.
Read the full guide →02 / WHY RESEARCHERS STUDY IT
Why CJC-1295 (no DAC) + IPA draws research interest
These are the areas researchers and the peptide community explore CJC-1295 (no DAC) + IPA for most often. They describe what is being studied — not proven benefits, approved uses, or promised results.
Bigger GH pulse
Two pathways together release more GH than either alone.
Body composition
Explored for lean mass and fat loss via GH and IGF-1.
Sleep & recovery
Studied for deep sleep and recovery tied to nightly GH.
Evidence ranges from early lab work to large clinical trials depending on the use — see the sections below for the data and sources.
03 / DOSING & RECONSTITUTION
Dosing & Reconstitution Guide
A single practical dilution with accurate dosing, step by step
Standard Approach (3 mL = 3.33 mg/mL)
- Reconstitute: Add 3 mL bacteriostatic water to one 10 mg vial → final concentration 3.33 mg/mL (3,333.3 mcg/mL).
- Typical range: 100–600 mcg 1–3x daily (am/workout/pm) · 5 on 2 off or daily, 3–6 months · fasted.
- Easy measuring: At 3.33 mg/mL, 1 unit ≈ 33.33 mcg on a U-100 syringe, so doses read at 3–18 units — a 0.3 mL (30-unit) syringe makes them easier to read.
- Storage: Lyophilized: store at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and do not freeze the mixed solution.
| Protocol | Dose range | Frequency | Cycle | Time off | Half-life | Fasted | Route |
|---|---|---|---|---|---|---|---|
| Injectable · Subq | 100–600 mcg | 1–3x daily (AM/Workout/PM) · 5 on 2 off or daily | 3–6 months | 4–8 weeks | Short (both components) | Yes | Subq |
04 / RECONSTITUTION CALCULATOR
Mix & measure CJC-1295 (no DAC) + IPA · 10 mg
Pre-filled with this protocol's recommended BAC water and starting dose — edit any field to run your own numbers.
- CONCENTRATION
- 3.33 mg/mL
- DRAW VOLUME
- 0.030 mL
- ON THE SYRINGE
- 3.0 units
- DOSES / VIAL
- 100
Reconstitution math only. U-100 syringe: 100 units = 1 mL.
Reconstitution GuideFull calculator →05 / STORAGE
Storage Instructions
Lyophilized (powder)
Store in the freezer at −20 °C (−4 °F) for long-term storage, or refrigerated at 2–8 °C for shorter periods. Keep dry, sealed and away from light. Let a frozen vial reach room temperature before opening to avoid condensation.
Reconstituted
Refrigerate at 2–8 °C (35.6–46.4 °F) and use within about 28 days. Do not freeze. Keep away from heat and direct light, and avoid repeated temperature swings. Swirl gently — never shake.
Reconstitution steps
- Wipe the vial stopper with an alcohol swab.
- Draw the BAC water and release it slowly down the inside wall of the vial.
- Swirl or roll gently until fully dissolved — don't shake.
- Label with the date and concentration and refrigerate.
06 / RESEARCH FINDINGS
What Research Shows
Unvalidated blend
- Growth-hormone signaling is the intended research target of this combination; clinical recovery or muscle-gain benefits are not established here.
- Benefits of a component do not demonstrate benefits of the finished blend.
Research context
The combination needs its own composition, compatibility, safety, and outcome data; no validated human benefit is established here.
07 / MOLECULAR BIOLOGY
Mechanism of Action
Mechanism unresolved
Proposed research targets
Growth-hormone signaling is the intended research target of this combination; clinical recovery or muscle-gain benefits are not established here.
The molecular target remains under investigation; analogs and blends require separate characterization.
Adamantane & the blood–brain barrier
Chemically attaching an adamantane group to a peptide can increase its lipid (fat) solubility. Researchers hypothesize that this modification may help certain compounds cross the tightly regulated blood–brain barrier. The effect depends on the specific modified molecule; greater lipid solubility alone does not establish brain delivery or clinical benefit. This does not apply automatically to the unmodified peptide and is not a reconstitution additive.
08 / LIFESTYLE FACTORS
Lifestyle Factors
- Sleep: aim for 7–9 hours; the largest natural GH pulse happens in deep sleep.
- Fasted dosing: dose away from meals — elevated insulin and carbs blunt the GH pulse.
- Training: pair with resistance training and real recovery days.
- Protein: keep protein intake adequate to support lean mass.
- Consistency: dose at the same time each day and rotate injection sites.
09 / BENEFITS & SIDE EFFECTS
Potential Benefits & Side Effects
Potential Benefits
- Deeper, more restorative sleep
- Improved recovery from training
- Gradual improvements in body composition (more lean mass, less fat)
- Better skin, hair and overall vitality reported over longer cycles
Side Effects
- Injection-site redness or irritation
- Water retention, tingling or numbness in hands
- Head rush, flushing or lightheadedness shortly after dosing
- Increased hunger (more with ghrelin-pathway peptides)
- Higher blood sugar at larger doses — monitor glucose and IGF-1
10 / STUDIES
Studies & references
11 / SAFETY
Safety considerations
- Verify the active identity, lot number, and matching certificate of analysis. Testing does not by itself establish sterility or suitability for human use.
- Follow documented product-specific storage and preparation requirements; stability and diluent compatibility depend on the formulation.
- Research powders are not interchangeable with prescription formulations. Do not infer an injection or nasal protocol from a concentration calculation.
- For medical care, pregnancy, existing conditions, or medication interactions, consult a qualified healthcare professional.
12 / RECOMMENDED SOURCE
Recommended Source
For research peptides, we point researchers to Orbitrex Peptides for CJC-1295 (no DAC) + IPA.
Why Orbitrex?
- Family-owned & independently tested: Multiple laboratories verify quality, with batch-specific testing in every COA.
- Everyday value: Buy 4, Get 1 Free on eligible products.
- Loyalty credit: 5% back in loyalty credit for future purchases.
- VerifyPass discount: 20% off for qualifying groups — stacks with affiliate codes.
- Free 2nd Day shipping: Free UPS 2nd Day Air on orders $200+, applied automatically at checkout.
All products are for research use only. Availability and offers subject to change.